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5 (S) -HEPE

CAT: 0931-T84567-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84567-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
92008-51-0
Target
Others
Related Pathways
Others
Bioactivity
5 (S) -HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO) . This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 μM concentration. Additionally, 5 (S) -HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5 (S) -HEPE are increased in hyperlipidemia patients.
Smiles
[C@@H](/C=C/C=C\C/C=C\C/C=C\C/C=C\CC)(CCCC(O)=O)O
Molecular Formula
C20H30O3
Molecular Weight
318.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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