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IcFSP1 TFA

CAT: 0931-T83886-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T83886-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others
Related Pathways
Others
Bioactivity
IcFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 μM concentration but does not affect FSP1's enzymatic function in cell-free assessments (IC50 = > 30 μM) . This compound selectively induces ferroptosis in HT-1080 fibrosarcoma cells in a dose-dependent manner. Furthermore, in vivo studies show that icFSP1 administered at 50 mg/kg significantly reduces both the volume and weight of tumors in a B16/F10 murine melanoma model utilizing human FSP1-overexpressing, Gpx4-/-Fsp1-/- B16/F10 cells.
Smiles
O=C1C2=C(N=C(C)N1C3=CC=C(NC(CC4=CC(OC)=C(C(OC)=C4)OC)=O)C=C3)C=CC=C2.OC(C(F)(F)F)=O
Molecular Formula
C26H25N3O5.CF3COOH
Molecular Weight
573.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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