EGFR-IN-55

• Target :

  EGFR|||Others

• Related Pathways :

  JAK/STAT signaling|||Others|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Bioactivity :

  EGFR-IN-55 is a potent inhibitor of EGFR, acting on EGFRWT (IC50: 70 nM) and EGFRL858R/T790M (IC50: 3.9 nM) . EGFR-IN-55 was able to block the cell cycle of NCI-H1975 cells in G0/G1 phase, exhibiting anticancer effects.

• Smiles :

  N(C1=CC=C(C=C1)N2CCN(C(C)=O)CC2)C=3N=C(NC4=CC(NC(C(=C)Cl)=O)=CC=C4)C(Cl)=CN3

• Molecular Formula :

  C25H25Cl2N7O2

• Molecular Weight :

  526.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2057423-46-6