EGFR-IN-55

CAT: 0931-MF-0049697-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0049697-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2057423-46-6
Target
EGFR|||Others
Related Pathways
JAK/STAT signaling|||Others|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
EGFR-IN-55 is a potent inhibitor of EGFR, acting on EGFRWT (IC50: 70 nM) and EGFRL858R/T790M (IC50: 3.9 nM) . EGFR-IN-55 was able to block the cell cycle of NCI-H1975 cells in G0/G1 phase, exhibiting anticancer effects.
Smiles
N(C1=CC=C(C=C1)N2CCN(C(C)=O)CC2)C=3N=C(NC4=CC(NC(C(=C)Cl)=O)=CC=C4)C(Cl)=CN3
Molecular Formula
C25H25Cl2N7O2
Molecular Weight
526.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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