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CL2A-SN38 (Govitecan)

CAT: 0013-GTR19259530-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259530-01Size:100 mg
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Description
CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC) . CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC) . CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .
CAS Number
1279680-68-0
Purity
0.98
Smiles
ClC ([H]) (C (=O) O[H]) Cl.ClC ([H]) (C (=O) O[H]) Cl.O=C (C1 ([H]) C ([H]) ([H]) C ([H]) ([H]) C ([H]) (C ([H]) ([H]) N2C (C ([H]) =C ([H]) C2=O) =O) C ([H]) ([H]) C1 ([H]) [H]) N ([H]) C ([H]) ([H]) C1=C ([H]) N (C ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) OC ([H]) ([H]) C ([H]) ([H]) N ([H]) C (C ([H]) ([H]) OC ([H]) ([H]) C (N ([H]) [C@] ([H]) (C (N ([H]) C2C ([H]) =C ([H]) C (=C ([H]) C=2[H]) C ([H]) ([H]) OC (=O) O[C@@]2 (C (=O) OC ([H]) ([H]) C3C (N4C ([H]) ([H]) C5=C (C ([H]) ([H]) C ([H]) ([H]) [H]) C6C ([H]) =C (C ([H]) =C ([H]) C=6N=C5C4=C ([H]) C2=3) O[H]) =O) C ([H]) ([H]) C ([H]) ([H]) [H]) =O) C ([H]) ([H]) C ([H]) ([H]) C ([H]) ([H]) C ([H]) ([H]) N ([H]) [H]) =O) =O) N=N1
Molecular Formula
C77H101CL4N11O26
Molecular Weight
1738.496
Notes
For research use only.

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