PI3Kα-IN-14

CAT: 0931-T81469-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T81469-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PI3K, Apoptosis

Related Pathways

PI3K/Akt/mTOR signaling, Apoptosis

Bioactivity

PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and significantly reduces mitochondrial membrane potential, leading to G1 phase cell cycle arrest and apoptosis in U87-MG cells. It also shows substantial antiproliferative effects against various tumor cell lines, including PC-3 (IC50 of 0.28 μM), HCT-116 (IC50 of 0.57 μM), and U87-MG (IC50 of 1.37 μM) [1].

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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PI3Kα-IN-14

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