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PI3Kδ-IN-14

CAT: 0804-HY-155975Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155975Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3Kδ-IN-14 (Compound (S) -29) is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM) . PI3Kδ-IN-14 binds to the ATP-binding site of the kinase domain of PI3Kδ. PI3Kδ-IN-14 has anti-inflammatory activity by inhibiting the PI3K/AKT pathway. PI3Kδ-IN-14 ameliorates acute lung injury (ALI) [1].
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-14.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C2C(N(N=C2[C@@H](N3C4=C(C(C5=CC(F)=C(C=C5)OC)=N3)C(N)=NC=N4)C)C6=CC=CN=C6)=C1
Molecular Formula
C26H20ClFN8O
Molecular Weight
514.94
References & Citations
[1]Tang Y, et al. Discovery of Highly Selective and Orally Bioavailable PI3K Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury. J Med Chem. 2023 Aug 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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