PNC-28

• Target:

  MDM-2/p53

• Related Pathways:

  Apoptosis

• Bioactivity:

  PNC-28, a peptide derived from the mdm-2-binding domain of p53 protein (residues 17–26), incorporates a membrane-crossing penetratin sequence. This compound is utilized in pancreatic cancer research [1] [2].

• Smiles:

  C([C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=2C=3C(NC2)=CC=CC3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC=4C=5C(NC4)=CC=CC5)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC6=CC=CC=C6)NC([C@@H](NC([C@H](CCC(O)=O)N)=O)[C@@H](C)O)=O)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)CCSC)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CCC(N)=O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(NCC(O)=O)=O)=O)CCC(N)=O)=O)[C@H](C)C)=O)CCCCN)=O)[C@@H](C)C)=O)C=7C=8C(NC7)=CC=CC8

• Molecular Formula:

  C164H255N47O37S

• Molecular Weight:

  3509.14

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  392661-17-5