ROCK-IN-9

• Target:

  ROCK

• Related Pathways:

  Cytoskeletal Signaling|||Stem Cells|||Cell Cycle/Checkpoint

• Bioactivity:

  ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 ?M. It demonstrates favorable pharmacokinetic properties in mice, achieving high in vivo exposure and oral bioavailability at low doses [1].

• Smiles:

  C(NCC1=CC(OC)=CC=C1)(=O)N2C=3C(=CC(=C(F)C3)C=4C(N)=NNC4)CC2

• Molecular Formula:

  C20H20FN5O2

• Molecular Weight:

  381.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2643334-76-1