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EGFR/CDK2-IN-4

CAT: 0931-T79729-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79729-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
EGFR, CDK
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Cell Cycle/Checkpoint, Angiogenesis
Bioactivity
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, with IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2. It induces apoptosis and S phase cell cycle arrest in MCF-7 cells, showing significant anti-cancer activity with an IC50 of 2.74 μM against MCF-7 cells [1].
Molecular Formula
C24H16N6OS2
Molecular Weight
468.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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