EGFR/CDK2-IN-3

CAT: 0931-T79728-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T79728-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

CDK, EGFR

Related Pathways

JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint

Bioactivity

EGFR/CDK2-IN-3 (compound 4b) is a dual inhibitor of EGFR and CDK-2 with IC50 values of 71.7 nM and 113.7 nM, respectively. It induces apoptosis in MCF-7 cells, arrests the cell cycle in the S phase, and exhibits significant anti-cancer cell toxicity, inhibiting MCF-7 cells with an IC50 of 3.16 μM [1].

Molecular Formula

C30H20N6OS

Molecular Weight

512.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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EGFR/CDK2-IN-3

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