ARD-1676

• Target :

  PROTACs|||Androgen Receptor

• Related Pathways :

  PROTAC|||Endocrinology/Hormones

• Bioactivity :

  ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activity both in vitro and in vivo, and effectively inhibits VCaP tumor growth in mouse xenograft models [1].

• Smiles :

  C[C@H]1CC2(CN1C3=CC(Cl)=C(C#N)C=C3)CCN(CC2)C4=CC=C(C(=O)N5CCC(CN6CC=7C(C6)=CC8=C(C7)C(=O)N(C8=O)C9C(=O)NC(=O)CC9)CC5)C=C4

• Molecular Formula :

  C44H46ClN7O5

• Molecular Weight :

  788.33

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2632305-36-1