JKE-1674

• Target:

  GPX|||Glutathione Peroxidase|||Ferroptosis

• Related Pathways:

  Metabolism|||Oxidation-Reduction|||Apoptosis

• Purity:

  0.9872

• Bioactivity:

  JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.

• Smiles:

  O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

• Molecular Formula:

  C20H20Cl2N4O4

• Molecular Weight:

  451.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2421119-60-8