JKE-1674

CAT: 0931-T37314-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T37314-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2421119-60-8

Target

GPX, Glutathione Peroxidase, Ferroptosis

Related Pathways

Metabolism, Oxidation-Reduction, Apoptosis

Purity

0.9872

Bioactivity

JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.

Smiles

O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

Molecular Formula

C20H20Cl2N4O4

Molecular Weight

451.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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JKE-1674

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