ARD-61

• Target:

  PROTACs|||Androgen Receptor|||Apoptosis|||Progesterone Receptor

• Related Pathways:

  Endocrinology/Hormones|||Others|||Apoptosis|||PROTAC

• Bioactivity:

  ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apoptosis. Additionally, ARD-61 demonstrates significant tumor growth inhibition in the MDA-MB-453 xenograft model in mice.

• Smiles:

  CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(CC1)N1CCC(CC1)C#Cc1ccc(cc1)C(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(Cl)c2)C1(C)C)c1ccc(cc1)-c1scnc1C)c1cc(C)no1

• Molecular Formula:

  C61H71ClN8O7S

• Molecular Weight:

  1095.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2316837-08-6