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STAT3-IN-20

CAT: 0931-T79662-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T79662-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2768427-54-7
Target
STAT
Related Pathways
JAK/STAT signaling, Stem Cells
Bioactivity
STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear translocation, and subsequent gene transcription. The compound demonstrates antiproliferative effects on DU145 and MDA-MB-231 cancer cell lines, which have overactivated STAT3, with IC50 values of 2.97 μM and 3.26 μM, respectively. Moreover, STAT3-IN-20 induces cell cycle arrest and apoptosis [1].
Smiles
N(C=1C=C2C(N(C(=N2)C3=CC=C(F)C=C3)C4CC4)=CC1N5CCN(C)CC5)C=6SC(=NN6)C7=CC=C(C(F)(F)F)C=C7
Molecular Formula
C30H27F4N7S
Molecular Weight
593.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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