STAT3-IN-38

• Target :

  Apoptosis|||STAT|||Survivin

• Related Pathways :

  Stem Cells|||JAK/STAT signaling|||Apoptosis

• Bioactivity :

  STAT3-IN-38 (Compound 4m) is a STAT3 inhibitor with a dissociation constant (K_D) of 45.33 µM for rhSTAT3, and is a derivative of Celastrol. It binds to the SH2 domain of the STAT3 protein, inhibiting phosphorylation at the pTyr705 site and suppressing downstream gene expression of Survivin and Mcl-1. STAT3-IN-38 can arrest the cell cycle and induce apoptosis in colorectal cancer cells.

• Smiles :

  C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(NCCC4=CC=CS4)=O)(C)C3)[H])CC[C@]5(C)C2=CC=C6C5=CC(=O)C(O)=C6C

• Molecular Formula :

  C35H45NO3S

• Molecular Weight :

  559.8

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3033049-16-7