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MAPK-IN-2

CAT: 0931-T79572-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T79572-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
CDK|||p38 MAPK|||c-Met/HGFR|||Raf|||EGFR
Related Pathways
MAPK|||Cell Cycle/Checkpoint|||Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Bioactivity
MAPK-IN-2 (compound 3h) is an efficacious MAPK inhibitor with antineoplastic properties that significantly hinders proliferation across various cancer cell lines. It demonstrates robust suppression of the MAPK pathway (EGFR WT IC50 = 281 nM, c-MET IC50 = 205 nM, B-RAF WT IC50 = 112 nM, CDK4/6 IC50 = 95 and 184 nM, respectively) and exhibits pronounced activity against mutated forms of EGFR and B-RAF (EGFR T790M IC50 = 69 nM and B-RAF V600E IC50 = 83 nM) [1].
Smiles
ClC1=CC=C(C(C=C(C2=CNC3=C2C=CC=C3)N4)=C(C#N)C4=O)C(Cl)=C1
Molecular Formula
C20H11Cl2N3O
Molecular Weight
380.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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