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MAPK-IN-3

CAT: 0931-T203402-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T203402-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2848599-79-9
Target
ERK|||MDM-2/p53|||JNK|||Reactive Oxygen Species|||p38 MAPK|||Bcl-2 Family|||Caspase|||CDK
Related Pathways
Proteases/Proteasome|||Cell Cycle/Checkpoint|||MAPK|||NF-?B|||Metabolism|||Apoptosis|||Immunology/Inflammation
Bioactivity
MAPK-IN-3 (Compound 4a) is an antiproliferative agent demonstrating significant inhibitory effects on KYSE 30, HCT 116, and HGC 27 cell lines, with IC50 values of 0.57 ?M, 3.27 ?M, and 2.28 ?M, respectively. This compound arrests the cell cycle via a p53-dependent mechanism and induces apoptosis through a p53-independent pathway. It reduces the expression of cell cycle-related proteins, such as Cyclin D1 and Cyclin B1, while increasing pro-apoptotic proteins like cleaved PARP, cleaved caspase-7, and cleaved caspase-9. MAPK-IN-3 also decreases anti-apoptotic proteins such as Bcl-2, elevates ROS levels in KYSE 30 cells, and enhances the expression of ROS-related MAPK pathway members, including p-ERK, p-p38, and p-JNK.
Smiles
O=C1C=2C(O)=C(C(OCC(=O)NO)=CC2OC=3C=C(OCC(=O)NO)C(OC)=C(C13)CC=C(C)C)CC=C(C)C
Molecular Formula
C28H32N2O10
Molecular Weight
556.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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