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TH-Z827

CAT: 0931-T79092-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: T79092-01Size: 5 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2847881-81-4
Target
Ras
Related Pathways
MAPK|||GPCR/G Protein
Bioactivity
TH-Z827 is a mutant-selective inhibitor targeting KRAS (G12D) with an IC50 of 2.4 ?M, demonstrating specificity by not binding to KRAS (WT) or KRAS (G12C) . Additionally, it disrupts the KRAS (G12D) -CRAF interaction with an IC50 of 42 ?M [1].
Smiles
O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6C7CCC6CNC7
Molecular Formula
C30H38N6O
Molecular Weight
498.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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