TH-Z827

• Target:

  Ras

• Related Pathways:

  MAPK|||GPCR/G Protein

• Bioactivity:

  TH-Z827 is a mutant-selective inhibitor targeting KRAS (G12D) with an IC50 of 2.4 ?M, demonstrating specificity by not binding to KRAS (WT) or KRAS (G12C) . Additionally, it disrupts the KRAS (G12D) -CRAF interaction with an IC50 of 42 ?M [1].

• Smiles:

  O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6C7CCC6CNC7

• Molecular Formula:

  C30H38N6O

• Molecular Weight:

  498.66

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2847881-81-4