TH-Z835

• Target :

  Apoptosis|||Ras

• Related Pathways :

  MAPK|||GPCR/G Protein|||Apoptosis

• Bioactivity :

  TH-Z835 is a mutant-selective KRAS (G12D) inhibitor with an IC50 of 1.6 ?M.This compound inhibits mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange.

• Smiles :

  O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6CC7NC(C6)CC7

• Molecular Formula :

  C30H38N6O

• Molecular Weight :

  498.66

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2766209-50-9