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PF15 TFA

CAT: 931-T77932-01Size: 5 mgDry Ice: NoHazardous: No
5 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs|||FLT
Related Pathways
Tyrosine Kinase/Adaptors|||PROTAC|||Angiogenesis
Bioactivity
PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM. The compound potently suppresses proliferation in FLT3-ITD-positive cells, reduces phosphorylation levels of FLT3 and STAT5, and demonstrates inhibition of tumor growth in murine leukemia models [1].
Molecular Formula
C46H50F3N13O8
Molecular Weight
969.97
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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