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PF15

CAT: 0931-T74259-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74259-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2892631-70-6
Target
PROTACs, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC
Bioactivity
PF15, a selective FLT3-ITD degrader, serves as a PROTAC (proteolysis targeting chimera) tethering ligands for FLT3 kinase and CRBN. It exhibits a degradation concentration 50 (DC50) of 76.7 nM and notably impedes the proliferation of FLT3-ITD-positive cells. PF15 also reduces phosphorylation levels of FLT3 and STAT5 and demonstrates efficacy in inhibiting tumor growth in mouse models, suggesting potential applications in leukemia research [1].
Smiles
NC1=C2C(=CN(CCCCC3=CN(CCCCC(NC4=C5C(C(=O)N(C5)C6C(=O)NC(=O)CC6)=CC=C4)=O)N=N3)C2=NC=N1)C7=CC=C(NC(NC=8C=C(C(C)(C)C)ON8)=O)C=C7
Molecular Formula
C44H49N13O6
Molecular Weight
855.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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