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P-gb-IN-1

CAT: 0931-T77575-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T77575-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2632874-49-6
Target
P-gp
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Purity
0.9985
Bioactivity
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 showed low toxicity in MCF-7/ADR cells.
Smiles
O=C(NC=1C=CC(=CC1)C=2OC(=CC2)C(=O)N3CC4=CC(OC)=C(OC)C=C4CC3)C5=CC=C(OC)C=C5
Molecular Formula
C30H28N2O6
Molecular Weight
512.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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