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GB-6

CAT: 0804-HY-P5520Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5520Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR) . GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].
CAS Number
2413262-74-3
UNSPSC
12352209
Target
Bombesin Receptor; Radionuclide-Drug Conjugates (RDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gb-6.html
Solubility
10 mM in DMSO
Smiles
N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC2=CC=C(O)C=C21)C(NCCC(N[C@@H](CCC)C(NCC(N[C@@H](CC3=CNC=N3)C(N)=O)=O)=O)=O)=O)=O
Molecular Formula
C32H45N11O8
Molecular Weight
711.77
References & Citations
[1]Tu Y, et al. Novel GRPR-Targeting Peptide for Pancreatic Cancer Molecular Imaging in Orthotopic and Liver Metastasis Mouse Models. Anal Chem. 2023 Aug 1;95 (30) :11429-11439.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
RDC Peptide

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