USP28-IN-4

• Target :

  DUB

• Related Pathways :

  Ubiquitination|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Purity :

  0.9848

• Bioactivity :

  USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 ?M against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorectal and lung squamous carcinoma cells and dose-dependently downregulates c-Myc cellular levels through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc.

• Smiles :

  O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C

• Molecular Formula :

  C22H18Cl2N2O3S

• Molecular Weight :

  461.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2931509-15-6