USP28-IN-2

• Target:

  Others|||DUB

• Related Pathways:

  Others|||Ubiquitination|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity:

  USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 ?M), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].

• Molecular Formula:

  C23H20Cl2N2O3S

• Molecular Weight:

  475.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2931509-11-2