USP28-IN-2

• CAS Number :

  2931509-11-2

• Target :

  Others|||DUB

• Related Pathways :

  Others|||Ubiquitination|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity :

  USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 ?M), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].

• Molecular Formula :

  C23H20Cl2N2O3S

• Molecular Weight :

  475.39

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C