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USP28-IN-2

CAT: 0931-T74792-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T74792-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2931509-11-2
Target
Others, DUB
Related Pathways
Others, Ubiquitination, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 μM), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].
Molecular Formula
C23H20Cl2N2O3S
Molecular Weight
475.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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