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USP28-IN-2

CAT: 0804-HY-149228Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149228Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib.
CAS Number
2931509-11-2
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/usp28-in-2.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(C1=CC=C(C(Cl)=C1)C(NC2=CC=C(C(C3=CC=C(C=C3)C4(CC4)N)=C2)Cl)=O)=O
Molecular Formula
C23H20Cl2N2O3S
Molecular Weight
475.39
References & Citations
[1]Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254:115369.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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