2,2,2-Trichloroethanol

CAT: 0931-MF-0040429Size: 500 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0040429Size:500 mg
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CAS Number
115-20-8
Target
Potassium Channel|||Endogenous Metabolite
Related Pathways
Metabolism|||Membrane transporter/Ion channel
Purity
0.9974
Bioactivity
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) . It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332 (3) :803-10.
Smiles
OCC(Cl)(Cl)Cl
Molecular Formula
C2H3Cl3O
Molecular Weight
149.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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