2,2,2-Trichloroethanol

• Target :

  Potassium Channel|||Endogenous Metabolite

• Related Pathways :

  Metabolism|||Membrane transporter/Ion channel

• Purity :

  0.9974

• Bioactivity :

  2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4) . It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332 (3) :803-10.

• Smiles :

  OCC(Cl)(Cl)Cl

• Molecular Formula :

  C2H3Cl3O

• Molecular Weight :

  149.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  115-20-8