Dideoxy-amanitin

• Target:

  DNA/RNA Synthesis|||ADC Cytotoxin

• Related Pathways:

  Antibody-drug Conjugate/ADC Related|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity:

  Dideoxy-amanitin (compound 2), a derivative of ?-Amanitin, functions as a potent, selective allosteric inhibitor of RNA polymerase II, demonstrating an inhibition concentration (IC50) of 74.2 nM [1].

• Smiles:

  [H][C@@]12C[C@@H](O)CN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CSc3[nH]c4ccccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1

• Molecular Formula:

  C39H54N10O12S

• Molecular Weight:

  886.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  58255-46-2