Dideoxy-amanitin

• Target:

  DNA/RNA Synthesis|||ADC Cytotoxin

• Related Pathways:

  Antibody-drug Conjugate/ADC Related|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity:

  Dideoxy-amanitin (compound 2), a derivative of ?-Amanitin, functions as a potent, selective allosteric inhibitor of RNA polymerase II, demonstrating an inhibition concentration (IC50) of 74.2 nM [1].

• Smiles:

  [H][C@@]12C[C@@H] (O) CN1C (=O) [C@H] (CC (N) =O) NC (=O) [C@]1 ([H]) CSc3[nH]c4ccccc4c3C[C@] ([H]) (NC (=O) [C@@] ([H]) (NC2=O) [C@@H] (C) [C@@H] (O) CO) C (=O) NCC (=O) N[C@@] ([H]) ([C@@H] (C) CC) C (=O) NCC (=O) N1

• Molecular Formula:

  C39H54N10O12S

• Molecular Weight:

  886.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  58255-46-2