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Dideoxy-amanitin

CAT: 0931-T74659-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T74659-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
58255-46-2
Target
DNA/RNA Synthesis|||ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Bioactivity
Dideoxy-amanitin (compound 2), a derivative of ?-Amanitin, functions as a potent, selective allosteric inhibitor of RNA polymerase II, demonstrating an inhibition concentration (IC50) of 74.2 nM [1].
Smiles
[H][C@@]12C[C@@H](O)CN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CSc3[nH]c4ccccc4c3C[C@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@@H](C)[C@@H](O)CO)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)CC)C(=O)NCC(=O)N1
Molecular Formula
C39H54N10O12S
Molecular Weight
886.97
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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