ε-Amanitin

CAT: 0804-HY-131083Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-131083Size:1 Each
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Description
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].
CAS Number
[21705-02-2]
UNSPSC
12352005
Target
ADC Payload; DNA/RNA Synthesis
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ε-amanitin.html
Solubility
10 mM in DMSO
Smiles
O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(O)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O
Molecular Formula
C39H53N9O14S
Molecular Weight
903.96
References & Citations
[1]Jan Grunewald, et al. Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase. WO2016071856A1.|[2]Kaya E, et al. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom. Toxicon. 2013;76:225-233.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents

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