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MS9427 TFA

CAT: 0931-T74634-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74634-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, PROTAC
Bioactivity
MS9427 TFA is a potent PROTAC-based EGFR degrader, exhibiting dissociation constants (Kd) of 7.1 nM for wild-type EGFR and 4.3 nM for the L858R EGFR mutation. It preferentially degrades the mutant EGFR, sparing the wild-type form, utilizing both the ubiquitin/proteasome system (UPS) and the autophagy/lysosome pathways. Its efficacy extends to the significant inhibition of non-small cell lung cancer (NSCLC) cell proliferation, indicating its potential utility in anticancer research [1].
Molecular Formula
C50H59ClF4N8O14
Molecular Weight
1107.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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