MS9427 TFA

• Target:

  PROTACs|||EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||PROTAC

• Bioactivity:

  MS9427 TFA is a potent PROTAC-based EGFR degrader, exhibiting dissociation constants (Kd) of 7.1 nM for wild-type EGFR and 4.3 nM for the L858R EGFR mutation. It preferentially degrades the mutant EGFR, sparing the wild-type form, utilizing both the ubiquitin/proteasome system (UPS) and the autophagy/lysosome pathways. Its efficacy extends to the significant inhibition of non-small cell lung cancer (NSCLC) cell proliferation, indicating its potential utility in anticancer research [1].

• Molecular Formula:

  C50H59ClF4N8O14

• Molecular Weight:

  1107.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C