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MS9427

CAT: 0931-T74633-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74633-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2772613-37-1
Target
EGFR, PROTACs, Others
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Others, Angiogenesis
Bioactivity
MS9427 is a potent PROTAC EGFR degrader with dissociation constants (K d s) of 7.1 nM for wild-type (WT) EGFR and 4.3 nM for L858R mutant EGFR, demonstrating selective degradation of the mutant via ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 effectively inhibits non-small cell lung cancer (NSCLC) cell proliferation, positioning it as a potential therapeutic agent in anticancer research [1].
Smiles
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCN(CC1)C(=O)CCOCCOCCOCCOCCOCCNc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1
Molecular Formula
C48H58ClFN8O12
Molecular Weight
993.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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