MS9427

• Target:

  EGFR|||PROTACs|||Others

• Related Pathways:

  PROTAC|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Others|||Angiogenesis

• Bioactivity:

  MS9427 is a potent PROTAC EGFR degrader with dissociation constants (K d s) of 7.1 nM for wild-type (WT) EGFR and 4.3 nM for L858R mutant EGFR, demonstrating selective degradation of the mutant via ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 effectively inhibits non-small cell lung cancer (NSCLC) cell proliferation, positioning it as a potential therapeutic agent in anticancer research [1].

• Smiles:

  COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCN(CC1)C(=O)CCOCCOCCOCCOCCOCCNc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1

• Molecular Formula:

  C48H58ClFN8O12

• Molecular Weight:

  993.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2772613-37-1