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Dot1L-IN-1 TFA

CAT: 0931-T73637-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T73637-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others, Histone Methyltransferase
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
Dot1L-IN-1 TFA is a potent and selective Dot1L inhibitor, with a K i of 2 pM and an IC50 of <0.1 nM. It effectively inhibits H3K79 dimethylation (IC50 = 3 nM) and suppresses HoxA9 promoter activity (IC50 = 17 nM) in HeLa and Molm-13 cells, respectively [1].
Molecular Formula
C34H37ClF3N9O4S
Molecular Weight
760.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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