Dot1L-IN-7

• Target:

  Histone Methyltransferase|||Others

• Related Pathways:

  Chromatin/Epigenetic|||Others

• Bioactivity:

  Dot1L-IN-7 (compound 25) is a selective and potent inhibitor of telomere silencing 1-like protein (DOT1L) with an IC50 of 1.0 ?M. It selectively kills MLL-AF9 cells without affecting the growth of E2A-HLF cells.

• Smiles:

  C(CNC(CN1N=C(C(NC2=CC=C(C(C)(C)C)C=C2)=O)N=C1)=O)N3C=4C(C=C3)=C(N)N=CN4

• Molecular Formula:

  C23H27N9O2

• Molecular Weight:

  461.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2580940-76-5