Dot1L-IN-8

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 ?M, respectively.

• Smiles:

  O=C1OCC(C)(C)CC=2C=3C=C(C=C4C3N(C2C5=CC(=CN=C5C(OC)C)N6CCOCC6)CCC4)C=7N=C(SC7)CC(NC(=O)C(N(C(=O)C8(F)CCN(C(=O)C(F)Cl)CC8)C)C(C)C)C(=O)N9NC1CCC9

• Molecular Formula:

  C41H53N7O3S

• Molecular Weight:

  723.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C