Dot1L-IN-2

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.

• Smiles:

  CC=1N(C=2C(C1)=CC=C(NC=3N=C(NC)C=CN3)C2)C4=C(OC=5C=C6C(=NC5)N(C)C=N6)C=CC=C4

• Molecular Formula:

  C27H24N8O

• Molecular Weight:

  476.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1940206-71-2