Nec-3a

CAT: 0804-HY-18899Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18899Size:1 Each
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Description
Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM) . Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
CAS Number
[1504558-72-8]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nec-3a.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1
Molecular Formula
C21H18F4N2O4
Molecular Weight
438.37
References & Citations
[1]Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21 (3) :493-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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