Nec-3a

• Description :

  Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM) . Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

• UNSPSC :

  12352005

• Target :

  RIP kinase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nec-3a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1

• Molecular Formula :

  C21H18F4N2O4

• Molecular Weight :

  438.37

• References & Citations :

  [1]Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21 (3) :493-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  RIPK1

• CAS Number :

  [1504558-72-8]