Nec-3a

Nec-3a

• CAS Number: 1504558-72-8
• UNSPSC Description: Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
• Target Antigen: RIP kinase
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nec-3a.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1
• Molecular Weight: 438.37
• References & Citations: [1]Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported