Nec-3a

• UNSPSC Description:

  Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

• Target Antigen:

  RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nec-3a.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1

• Molecular Weight:

  438.37

• References & Citations:

  [1]Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1504558-72-8