Nec-4

• Description :

  Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.

• UNSPSC :

  12352005

• Target :

  RIP kinase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Nec-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H](C1=C(C=CC=C1Cl)F)NC(C2=CC=C(N2C)C#N)=O

• Molecular Formula :

  C15H13ClFN3O

• Molecular Weight :

  305.73

• References & Citations :

  [1]Maki JL, et al. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15;427 (2) :164-74.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1041644-43-2]