Nec-4

CAT: 0804-HY-18900Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18900Size:1 Each
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Description
Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
CAS Number
[1041644-43-2]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Nec-4.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=C(C=CC=C1Cl)F)NC(C2=CC=C(N2C)C#N)=O
Molecular Formula
C15H13ClFN3O
Molecular Weight
305.73
References & Citations
[1]Maki JL, et al. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15;427 (2) :164-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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