THZ1 Hydrochloride

• Target :

  Others|||CDK

• Related Pathways :

  Others|||Cell Cycle/Checkpoint

• Bioactivity :

  THZ1 Hydrochloride is a potent, selective covalent inhibitor of CDK7, exhibiting an IC50 value of 3.2 nM. It also targets closely related kinases CDK12 and CDK13, leading to the downregulation of MYC expression.

• Smiles :

  CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl.Cl

• Molecular Formula :

  C31H29Cl2N7O2

• Molecular Weight :

  602.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C