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MTK458

CAT: 0931-T72420-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T72420-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2499962-58-0
Target
Mitochondrial Metabolism, Mitophagy, PTEN
Related Pathways
Metabolism, Autophagy, PI3K/Akt/mTOR signaling
Purity
0.9836
Bioactivity
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.
Smiles
N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4
Molecular Formula
C17H15F3N4
Molecular Weight
332.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-152943-01MTK458
HY-152943A(Rac) -MTK458

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