MTK458

• CAS Number :

  2499962-58-0

• Target :

  Mitochondrial Metabolism|||Mitophagy|||PTEN

• Related Pathways :

  Metabolism|||Autophagy|||PI3K/Akt/mTOR signaling

• Purity :

  0.9836

• Bioactivity :

  MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.

• Smiles :

  N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4

• Molecular Formula :

  C17H15F3N4

• Molecular Weight :

  332.32

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C