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MTK458

CAT: 0013-GTR19212792-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212792-01Size:1 mg
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Description
MTK458 (EP-0035985) is an orally bioavailable, brain-penetrant small molecule activator of PINK1. It promotes the clearance of pathological alpha-synuclein in preclinical models, such as the PFF inoculation model, by stabilizing the PINK1/TOM complex. This compound is a valuable research tool for investigating Parkinson's disease mechanisms and potential therapeutic strategies.
CAS Number
2499962-58-0
Product Name Alternative
Mitophagy activator 1, EP-0035985, PTEN-induced kinase 1 (PINK1)
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.36% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (9.93 mM) ; DMSO:80 mg/mL (240.73 mM)
Smiles
N (C1=C2C (NC (C (F) (F) F) =C2) =NC=N1) [C@H]3C=4C (CCC3) =CC=CC4
Molecular Formula
C17H15F3N4
Molecular Weight
332.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mitophagy activator 1
CAS Number2499962-58-0
PubChem CID155187445
IUPAC NameN-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Molecular FormulaC17H15F3N4
Molecular Weight332.32
XLogP4.2
Topological Polar Surface Area53.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity444
SMILES
C1C[C@H](C2=CC=CC=C2C1)NC3=NC=NC4=C3C=C(N4)C(F)(F)F
InChI
InChI=1S/C17H15F3N4/c18-17(19,20)14-8-12-15(21-9-22-16(12)24-14)23-13-7-3-5-10-4-1-2-6-11(10)13/h1-2,4,6,8-9,13H,3,5,7H2,(H2,21,22,23,24)/t13-/m1/s1
InChIKey
JOIONRWKOGDQOG-CYBMUJFWSA-N
Chemical Structure
2D Structure
2D structure of Mitophagy activator 1
CAS: 2499962-58-0
CID: 155187445
Formula: C17H15F3N4
MW: 332.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.32
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass332.12488098
Monoisotopic Mass332.12488098
Topological Polar Surface Area53.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity444
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T72420-01MTK458
HY-152943A(Rac) -MTK458

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