(Rac) -MTK458

• Description :

  (Rac) -MTK458 (compound 16) is an activator of mitophagy. EP-0035985 is the isomer of EP-0035985[1].

• CAS Number :

  [2499962-44-4]

• Product Name Alternative :

  (Rac) -EP-0035985

• UNSPSC :

  12352005

• Target :

  Mitophagy

• Type :

  Reference compound

• Related Pathways :

  Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rac-mtk458.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(F)(C1=CC2=C(NC3C4=C(CCC3)C=CC=C4)N=CN=C2N1)F

• Molecular Formula :

  C17H15F3N4

• Molecular Weight :

  332.32

• References & Citations :

  [1]De Roulet D, et al. Preparation of purinamines and pyrrolopyrimidinamines, compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease. World Intellectual Property Organization, WO2020206363 A1 2020-10-08.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported