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MTK458

CAT: 0931-T72420-03Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T72420-03Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2499962-58-0
Target
Mitochondrial Metabolism, Mitophagy, PTEN
Related Pathways
Metabolism, Autophagy, PI3K/Akt/mTOR signaling
Purity
0.9836
Bioactivity
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.
Smiles
N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4
Molecular Formula
C17H15F3N4
Molecular Weight
332.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Mitophagy activator 1
CAS Number2499962-58-0
PubChem CID155187445
IUPAC NameN-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Molecular FormulaC17H15F3N4
Molecular Weight332.32
XLogP4.2
Topological Polar Surface Area53.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity444
SMILES
C1C[C@H](C2=CC=CC=C2C1)NC3=NC=NC4=C3C=C(N4)C(F)(F)F
InChI
InChI=1S/C17H15F3N4/c18-17(19,20)14-8-12-15(21-9-22-16(12)24-14)23-13-7-3-5-10-4-1-2-6-11(10)13/h1-2,4,6,8-9,13H,3,5,7H2,(H2,21,22,23,24)/t13-/m1/s1
InChIKey
JOIONRWKOGDQOG-CYBMUJFWSA-N
Chemical Structure
2D Structure
2D structure of Mitophagy activator 1
CAS: 2499962-58-0
CID: 155187445
Formula: C17H15F3N4
MW: 332.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.32
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass332.12488098
Monoisotopic Mass332.12488098
Topological Polar Surface Area53.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity444
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-152943-01MTK458
HY-152943A(Rac) -MTK458

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