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β2AR/M-receptor agonist-2

CAT: 0931-T72226-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72226-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1017857-38-3
Target
AChR, Others, Adrenergic Receptor
Related Pathways
GPCR/G Protein, Others, Neuroscience
Bioactivity
β2AR/M-receptor agonist-2 is a dual-function compound acting as a muscarinic antagonist and β2 adrenoceptor agonist (MABA) . It demonstrates significant activity towards the β2 adrenoceptor with an EC50 of 3.7 nM and exhibits affinity for the human cloned M3 receptor with a Ki of 0.73 nM. This potent bronchodilator holds potential for research in chronic obstructive pulmonary disease (COPD) treatment.
Smiles
N(C(OC1CCN(CCCCCCCCCNC[C@H](O)C2=CC(NS(C)(=O)=O)=C(O)C=C2)CC1)=O)C3=C(C=CC=C3)C4=CC(Cl)=C(O)C=C4
Molecular Formula
C36H49ClN4O7S
Molecular Weight
717.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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