MK-1496

• CAS Number :

  1037254-47-9

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .

• Smiles :

  [C@H](CNC(C)(C)C)(O)C1=CC=C([C@H](C)N)C=C1

• Molecular Formula :

  C14H24N2O

• Molecular Weight :

  236.35

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C