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MK-1496

CAT: 0931-T71556-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71556-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1037254-47-9
Target
Others
Related Pathways
Others
Bioactivity
MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .
Smiles
[C@H](CNC(C)(C)C)(O)C1=CC=C([C@H](C)N)C=C1
Molecular Formula
C14H24N2O
Molecular Weight
236.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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