MK-1496

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .

• Smiles:

  [C@H] (CNC (C) (C) C) (O) C1=CC=C ([C@H] (C) N) C=C1

• Molecular Formula:

  C14H24N2O

• Molecular Weight:

  236.35

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1037254-47-9