MK-0493

CAT: 0931-T16086-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T16086-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

455956-93-1

Target

Melanocortin Receptor, Others

Related Pathways

Others, GPCR/G Protein, Neuroscience

Bioactivity

MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R) . It also demonstrated significant reductions in energy intake.

Smiles

C[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C

Molecular Formula

C30H38ClF2N3O2

Molecular Weight

546.09

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

MK-0493 free base

CAS Number	455956-93-1
PubChem CID	11642422
IUPAC Name	N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]ethyl]acetamide
Molecular Formula	C30H38ClF2N3O2
Molecular Weight	546.1
XLogP	4.8
Topological Polar Surface Area	52.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	38
Formal Charge	0
Complexity	831

SMILES

C[C@@H](C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)[C@@H]3CN(C[C@H]3C4=C(C=C(C=C4)F)F)C(C)(C)C)NC(=O)C

InChI

InChI=1S/C30H38ClF2N3O2/c1-18(34-19(2)37)25-14-21(31)6-8-23(25)20-10-12-35(13-11-20)29(38)27-17-36(30(3,4)5)16-26(27)24-9-7-22(32)15-28(24)33/h6-9,14-15,18,20,26-27H,10-13,16-17H2,1-5H3,(H,34,37)/t18-,26-,27+/m0/s1

InChIKey

ZCWVNCMFYHPHCX-RHLLTPQKSA-N

Chemical Structure

2D Structure

CAS: 455956-93-1

CID: 11642422

Formula: C30H38ClF2N3O2

MW: 546.1

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	546.1
XLogP3	4.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	545.2620615
Monoisotopic Mass	545.2620615
Topological Polar Surface Area	52.7 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	831
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA5544-10	MK-0493
GTR19193526-01	MK-0493 HCl
HY-118930A-01	MK-0493 (hydrochloride)
324068-01	MK
167912	Midkine (MK, MK1, MK-1, MK 1) discontinued
MBS131426	MK-4101 (MK 4101; MK4101)
MBS131418	Doravirine (MK-1439; MK1439; MK 1439)
456310-01	MK 677
MKB78162-01	MK-0674
MBS5753488	MK 0893

MK-0493

Chemical Information

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