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Afegostat TFA

CAT: 0931-T71476-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71476-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1084896-50-3
Target
Others, glycosidase
Related Pathways
Others, Metabolism
Bioactivity
Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K (i) ~30 nM for wild-type and mutant enzymes (N370S and V394L) . Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.
Smiles
C(C(O)=O)(F)(F)F.C(O)[C@@H]1[C@@H](O)[C@H](O)CNC1
Molecular Formula
C8H14F3NO5
Molecular Weight
261.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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