Afegostat (TFA)

CAT: 0804-HY-14829HSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14829HSize:1 Each
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Description
Afegostat TFA is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
CAS Number
[1084896-50-3]
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/afegostat-tfa.html
Smiles
OC(C(F)(F)F)=O.OC[C@@H]1[C@H]([C@@H](CNC1)O)O
Molecular Formula
C8H14F3NO5
Molecular Weight
261.20
References & Citations
[1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11 (4) :840-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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