APTO-253 isomer

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4) . This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.

• Smiles:

  CC1=C (C=2NC=3C (=C4C (=C5C3C=CC=N5) N=CC=C4) N2) C=6C (N1) =CC (F) =CC6

• Molecular Formula:

  C22H14FN5

• Molecular Weight:

  367.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1422826-80-9