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APTO-253 isomer

CAT: 0931-T70706-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70706-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1422826-80-9
Target
Others
Related Pathways
Others
Bioactivity
APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4) . This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
Smiles
CC1=C(C=2NC=3C(=C4C(=C5C3C=CC=N5)N=CC=C4)N2)C=6C(N1)=CC(F)=CC6
Molecular Formula
C22H14FN5
Molecular Weight
367.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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