AC 253

• Target:

  Beta Amyloid

• Related Pathways:

  Neuroscience

• Bioactivity:

  Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric A?-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of A? in vitro. Cyclic AC 253 also available.

• Smiles:

  C([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC(C)C)NC(C)=O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(N)=O)=O)[C@@H](C)O)=O)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)CO)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC3

• Molecular Formula:

  C122H196N40O39

• Molecular Weight:

  2847.11

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  151804-79-4