APS-2-79

• CAS Number :

  2002381-25-9

• Target :

  Others|||MEK

• Related Pathways :

  MAPK|||Others

• Bioactivity :

  APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes oncogenic Ras-MAPK signaling.

• Smiles :

  COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3C)c2cc1OC

• Molecular Formula :

  C23H21N3O3

• Molecular Weight :

  387.43

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C